Carazo Fernández Alejandro Ph.D.

Carazo Fernández Alejandro Ph.D.'s picture
Academic Title: Ldo.
Phone: +420774898043, +420585632181
Curriculum Vitae: download
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13.  Effect of endocannabinoid oleamide on rat and human liver cytochrome P450 enzymes in in vitro and in vivo models.

Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P.

Drug Metab Dispos. 2018 Apr 12. pii: dmd.117.079582. doi: 10.1124/dmd.117.079582. [Epub ahead of print] PMID: 29650790

12.  Unexpected effects of propiconazole, tebuconazole and their mixture on the receptors CAR and PXR in human liver cells.

Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.

Toxicol Sci. 2018 Feb 6. doi: 10.1093/toxsci/kfy026. [Epub ahead of print] PMID: 29420809

 

11.  Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats.

Dolezelova E, Prasnicka A, Cermanova J, Carazo A, Hyrsova L, Hroch M, Mokry J, Adamcova M, Mrkvicova A, Pavek P, Micuda S.

World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. doi: 10.3748/wjg.v23.i43.7678. PMID: 29209109

 

10.  Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

Prasnicka A, Cermanova J, Hroch M, Dolezelova E, Rozkydalova L, Smutny T, Carazo A, Chladek J, Lenicek M, Nachtigal P, Vitek L, Pavek P, Micuda S.

Biochim Biophys Acta. 2017 Dec;1862(12):1469-1480. doi: 10.1016/j.bbalip.2017.09.003. Epub 2017 Sep 6. PMID: 28888833

 

9.  Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.

Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P.

Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. Epub 2017 Sep 5. PMID: 28887089

 

8.    Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.

Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A.

Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476. doi: 10.1016/j.bmc.2017.08.010. Epub 2017 Aug 8. PMID: 28835350

 

7.    S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.

Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.

Eur J Med Chem. 2017 Jan 27;126:369-383. doi: 10.1016/j.ejmech.2016.11.041. Epub 2016 Nov 21. PMID: 27907875

 

6.    Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.

Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.

Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18. PMID: 27871908

 

5.    2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.

Smutny T, Nova A, Drechslerová M, Carazo A, Hyrsova L, Hrušková ZR, Kuneš J, Pour M, Špulák M, Pavek P.

J Med Chem. 2016 May 26;59(10):4601-10. doi: 10.1021/acs.jmedchem.5b01891. Epub 2016 May 12. PMID: 27145071

 

4.    The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.

Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S, Pavek P.

Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8. PMID: 26920453

 

3.    The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists.

Carazo A, Pávek P.

Sensors (Basel). 2015 Apr 21;15(4):9265-76. doi: 10.3390/s150409265. PMID: 25905697

 

2.    Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).

Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P.

Toxicol Lett. 2015 Mar 4;233(2):68-77. doi: 10.1016/j.toxlet.2015.01.013. Epub 2015 Jan 24. PMID: 25625231

 

1.    The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients.

Soukup T, Dosedel M, Pavek P, Nekvindova J, Barvik I, Bubancova I, Bradna P, Kubena AA, Carazo AF, Veleta T, Vlcek J.

Rheumatol Int. 2015 Jul;35(7):1149-61. doi: 10.1007/s00296-015-3219-z. Epub 2015 Jan 25. PMID: 25618758