Graduated master students

Bačová Zuzana M.Sc.'s picture

Zuzana Bačová

Master training

Status: Graduated 2013 to 2015
Gene expression profiling in hematological malignancies
The main objective of the study is to profile gene expression in hematological malignancies to find specific novel predictive and prognostic biomarkers using modern microarray technology and transcriptomic sequencing.
Borková Lucie M.Sc.'s picture

Lucie Borková

Master training

Supervisor:
Status: Graduated 2012 to 2014
Modification of the position 2 in betulin, allobetulin and betulinic acid with polar substituents
The main aim of the study is to modify lupane and 18-αoleanane triterpenoids in order to obtain a set of new derivatives with higher cytotoxicity and better solubility than the starting material.
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Lucie Broskevičová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Typing of systemic amyloidosis using mass spectrometry-based proteomic analysis
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Tereza Buchtová

Master training

Supervisor:
Status: Graduated 2016 to 2018
DNA demage responses in BRCA1 KO Sus Srofa cell line
Crlíková Hana's picture

Hana Crlíková

Master training

Supervisor:
Status: Graduated 2015 to 2016
Stabilisation of PCR reagents for storing at room temperature
Vypracováním teoretické části diplomové práce student prokáže schopnost orientovat se v tématech skladování bioreagencií pro PCR, pracovat s odbornými cizojazyčnými texty a řádně citovat. V praktické části student prokáže schopnost samostatně naplánovat, provést a vyhodnotit laboratorní experiment, týkající se PCR, inhibičních řad a testování stability DNA
Cvancigerová Monika's picture

Monika Cvancigerová

Master training

Status: Graduated 2015 to 2017
Genetic factors of sarcoidosis
Černínová Veronika's picture

Veronika Černínová

Master training

Status: Graduated 2014 to 2016
Preparation of new derivatives of the imidazopyridine with potential CNS activity
Dostálová Kristýna's picture

Kristýna Dostálová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Cell-based assays for high-throughput screening in drug discovery
Drábková Petra B.Sc.'s picture

Petra Drábková

Master training

Status: Graduated 2014 to 2016
Solid-phase synthesis of novel tricyclic heterocycles with 4-chloro-2-fluoro-5-nitrobenzoic acid
Master’s thesis is focused on solid-phase preparation of heterocycles with three condensed cycles combined benzodiazepine structure and six or seven member heterocycles using multi-reactive building block 4-chloro-2-fluoro-5-nitrobenzoic acid.
Flašarová Dominika's picture

Dominika Flašarová

Master training

Status: Graduated 2016 to 2018
KRAS signalling pathway in relation to pancreatic ductal adenocarcinoma
Gabčová Gabriela B.Sc.'s picture

Gabriela Gabčová

Master training

Supervisor:
Status: Graduated 2010 to 2015
Detection of predictive genetic oncomarkers of EGFR signalling pathway using sequencing technologies
The thesis is reviewing PCR-based methods of mutation detection in NRAS gene while experimental part is focused on pyrosequencing.
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Michaela Galoczova

Master training

Status: Graduated 2013 to 2015
Metabolomic analysis of the urine of newborns with perinatal asphyxia
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Klára Habartova

Master training

Status: Graduated 2013 to 2015
Biochemical analysis of joint effusion
Halouzková Barbora Agatha's picture

Barbora Agatha Halouzková

Master training

Supervisor:
Status: Graduated 2013 to 2015
Development of new chromatographic methods for the determination of plasma and urinary metanephrines
Hanáková Kristýna's picture

Kristýna Hanáková

Master training

Supervisor:
Status: Graduated 2011 to 2016
Study of modification of selected inhibitors of cyclin-dependent kinases targeted for biological transport
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Marek Handl

Master training

Supervisor:
Status: Graduated 2013 to 2015
Distinctive effect of phenylpropanoids in ginger plant against acute T-lymphoblastic leukemia cells
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Richard Hekele

Master training

Status: Graduated 2014 to 2016
Synthesis of trisubstituted derivatives of 4H-benzo triazole diazepin one on solid phase using an alpha-amino acid
This work is based on the solid-phase synthesis of trisubstituted 4H-benzotriazolodiazepinone derivatives utilizing alpha-amino acids. Used procedure comes from recently published findings of Fülöpová and Soural, and it is aimed at the synthesis of small library followed by biological screening (especially CNS activity).
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Alžběta Herodesová

Master training

Status: Graduated 2015
Determination and clinical significance of genetic variants at risk of recurrent Crohn's disease
SVOČ 2015
Hodoň Jiří's picture

Jiří Hodoň

Master training

Supervisor:
Status: Graduated 2015 to 2017
Cytotoxic active triterpenes and their mechanism of action
The main goals of this work is to prepare a set of triterpenoid derivatives that have shown high selective cytotoxicity and synthesize biotinylated probes from them that may be used in pull down essays in order to try to find molecular targets. Also, new derivatives will be studied for their interference with cell cycle and DNA/RNA synthesis in cancer cells.
Holá Michaela MSc.'s picture

Michaela Holá

Master training

Supervisor:
Status: Graduated 2015 to 2017
Gallium-68 labelled RGD peptides evaluation for imaging of glioblastoma multiforme
The thesis is focused into critical evaluation of three different RGD peptides coupled with chelators to enable their radiolabelling with gallium-68. RGD peptides are accumulated in tumors expressing αvβ3 integrin (marker of angiogenesis). Such radiolabelled RGD peptides could be succesfully used to image tumors in vivo. Our study will include all appropriate stages of radiopharmaceutical testing i.e. optimalisation of lablelling conditions, radiochemical purity tests (HPLC, TLC), plasma stability assays, testing of stability in various chemical enviroments, octanol-water partition coefficient determination. Suitable derivatives will be passed to in vitro tests employing cell line U-87 MG (glioblastoma multiforme) to assess their ability to bind to tumor cells. Finally the appropriate candidates will be used for in vivo imaging of gliomas in mouse model. The imaging will be carried out in microPET/CT system and its results will be compared with ex vivo biodistribution study.
Hollan Miloš's picture

Miloš Hollan

Master training

Status: Graduated 2014 to 2016
Use hydroxylamines for determination of peroxide compounds
Hrušková Eva B.Sc.'s picture

Eva Hrušková

Master training

Supervisor:
Status: Graduated 2010 to 2015
Testing the temperature uniformity of the thermocyclers using melting temperature of the same amplicon
The thesis is reviewing calibration methods of thermal cyclers and the experimental part is focused on the using of melting temperature of the same amplicon as a new approach of calibration.
Hušková Zlata B.Sc.'s picture

Zlata Hušková

Master training

Status: Graduated 2013 to 2015
Molecular mechanisms of plant steroids and study of their receptor interactions in cancer cells
The aim of the study is to find mechanisms of action of the plant steroids in human prostate cancer cells using cellular and molecular techniques indicated the possible involvement of steroid receptors in their action.
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Romana Christová

Master training

Supervisor:
Status: Graduated 2017 to 2018
Radiolabelled siderophore derivatives for detection of cancer and infection
katerina.janikova01@upol.cz's picture

Kateřina Janíková

Master training

Supervisor:
Status: Graduated 2014 to 2016
Utilization of Chan-Lam Cross-Coupling Reaction for derivatization of heterocyclic systems containing imidazole ring
Jenčíková Barbora's picture

Barbora Jenčíková

Master training

Supervisor:
Status: Graduated 2015 to 2017
Expression of opioid receptors and its influence on the treatment of gastrointestinal cancer patients
Kocmanová Leona's picture

Leona Kocmanová

Master training

Supervisor:
Status: Graduated 2013 to 2015
Synthesis of Oxazine Derivatives on Solid Support
Kotková Lucie's picture

Lucie Kotková

Master training

Status: Graduated 2015 to 2017
Optimization of library preparation for NGS
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Ondřej Kováč

Master training

Supervisor:
Status: Graduated 2011 to 2016
Nitrogen analogs and striga lactones mimetics
Králová Petra's picture

Petra Králová

Master training

Status: Graduated 2014 to 2016
Solid-Phase Synthesis of Novel Morpholine/Thiomorpholine-3-Carboxylic Acid Derivatives
This diploma thesis deals with the preparation of novel morpholine/thiomorpholine-3-carboxylic acids derivatives with use of solid phase synthesis. The starting materials for the preparation of target compounds are four types of resin with acid-labile linkers, natural α-amino acids, sulfonyl chlorides, α-bromoacetophenones, carboxylic acids or their chlorides, trifluoroacetic acid and reducing agent (triethylsilane). The Theoretical section is devoted to the literature summarizing methods for the preparation of the target derivatives. In the Discussion part there are described issues concerning the preparation of the desired compounds. The Experimental section presents general procedures for the preparation and isolation of these derivatives followed by analytical data of the individual substances. The Conclusion part summarizes our results and their evaluation. In the last part, there are attached annexes of the prepared compounds.
michal.kriegelstein01@upol.cz's picture

Michal Kriegelstein

Master training

Supervisor:
Status: Graduated 2014 to 2016
Synthesis of some derivatives of 1-(1H-indazol-3-yl)-1H-benzo[d]imidazol-2(3H)-one substitued in positions 5 and 6
Lasák Pavel's picture

Pavel Lasák

Master training

Supervisor:
Status: Graduated 2014 to 2016
Synthesis of benzo[c]phenanthridine alkaloids analogues
Liptay Martin's picture

Martin Liptay

Master training

Supervisor:
Status: Graduated 2012 to 2016
Post-translational modifications of RNF168 E3 ubiquitin ligase
Loubalová Zuzana's picture

Zuzana Loubalová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Cytogenetic changes in colorectal cancer patients
Master’s thesis is focused on cytogenetic changes in colorectal cancer patients. The student will propose and construct series of DNA probes suitable for fluorescence in situ hybridizations (FISH). By using this set will be possible to describe degree of deletions on q-arm of chromosome 18. Deletions of 18q involve DCC gene and are often find in colorectal cancer patients. The impact of this mutation is still discussed and the data are not consitent. As was newly found, in this region other 3 genes responsible for chomosome instability are located. Therfore is possible that for clinical imact would be important the the degree of the deletion.
Mádrová Lucie M.Sc's picture

Lucie Mádrová

Master training

Supervisor:
Status: Graduated 2013 to 2015
Usage of lipid profile for study of inherited metabolic disorders
The aim of the study is to optimize LCMS method with focus on polar lipids and their subsequent identification by fragmentation spectra and spectral trees. The final step will be the application of this method on biological samples, statistical evaluation of the data and metabolite identification based fragmentation patterns.
Machálková Markéta's picture

Markéta Machálková

Master training

Supervisor:
Status: Graduated 2013 to 2015
LC-MS analýza vybraných fosfatidylcholinů v lidské plazmě
Michalcová Kristýna's picture

Kristýna Michalcová

Master training

Supervisor:
Status: Graduated 2015 to 2017
Epigenetic resolution monozygotic twins
Němcová Kamila's picture

Kamila Němcová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Checking the integrity of the genome in cancer stem cells of prostate cancer
Neubauerová Eva's picture

Eva Neubauerová

Master training

Status: Graduated 2014 to 2016
Identification of molecular targets by proteomic methods
Ondra Martin's picture

Martin Ondra

Master training

Status: Graduated 2015 to 2017
Cellular model of ribosomal stress
Ondrouch Jakub B.Sc.'s picture

Jakub Ondrouch

Master training

Status: Graduated 2015
miRNA expression profiling in oesophageal disease
The microarray technology can measure expression of thousands miRNAs in parallel. The main objective of the study is to profile miRNA expression in oesophageal disease to find specific biomarkers for better diagnosis and therapy using microarray technology.
Pastorková Barbora B.Sc.'s picture

Barbora Pastorková

Master training

Status: Graduated 2013 to 2014
Identification of molecular targets of anticancer drugs by immuno-affinity purification
The aim of the study is to identify possible molecular targets of anti-tumour indazole derivatives by immuno-affinity purification and MS analysis.
Pavlíková Stanislava's picture

Stanislava Pavlíková

Master training

Status: Graduated 2013 to 2015
Diagnosis of selected inherited metabolic disorders of newborn screening by HPLC-MS / MS
Rašková Vendula B.Sc.'s picture

Vendula Rašková

Master training

Supervisor:
Status: Graduated 2013 to 2016
Proteomics of cervical fluid
The aim of the study is to find specific biomarkers for prediction of successful in vitro fertilization in cervical mucus.
Rezková Helena's picture

Helena Rezková

Master training

Supervisor:
Status: Graduated 2013 to 2015
Metabolite profiling of tyrosine kinase inhibitors in the plasma of patients with chronic myeloid leukemia
Ručilová Veronika Ph.D.'s picture

Veronika Ručilová

Master training

Supervisor:
Status: Graduated 2009 to 2011
Preparation of bisheterocyclic derivatives of 3-hydroxy-4(1H)-quinolinone-7-carboxamides
The focus of the submitted Diploma thesis is the solid phase synthesis of new bisheterocyclic derivatives of 2-substituted-3-hydroxyquinolin-4(1H)-one-7-carboxamides. The first part of literature search summarizes the threee main points: synthesis, biological and fluorescence properties of known derivatives of hydroxyquinolones. The conclusion of the theoretical part is devoted to the synthesis of o-phenylenediamines which are used as a building bloks of nitrogen heterocycles. The experimental part is focused on the development and optimalization of the above mentioned precursores . There are also attempts to a cyclization of correspondent intermediate to benzimidazole-hydroxyquinolones.
Růžičková Eliška B.Sc.'s picture

Eliška Růžičková

Master training

Status: Graduated 2013 to 2014
Evaluation of biological activity of demethylation drugs
The aim of the study is to prepare resistant cell lines to 5-azacytidine and characterise multidrug resistance to epigenetic therapeutics.
Sikorová Kateřina B.Sc.'s picture

Kateřina Sikorová

Master training

Status: Graduated 2015
Quantification of methylation by pyrosequencing in hemato-onkological diseases
The aim of the study is quantification of DNA methylation in selected genes – by pyrosequencing method, in two related hemato-oncological disease: Myelodysplastic syndromes (MDS) and Acute myeloid leukemia (AML).
Slavík Hanuš M.Sc.'s picture

Hanuš Slavík

Master training

Status: Graduated 2012 to 2014
Effect of analgesia on circulating tumor cells levels in colorectal cancer patients
Smitalová Dagmar's picture

Dagmar Smitalová

Master training

Status: Graduated 2014 to 2015
Extracellular expression of microRNA in pulmonary sarcoidosis
Spurná Ivana's picture

Ivana Spurná

Master training

Supervisor:
Status: Graduated 2013 to 2014
Study catalyzed and nekatalyzovaných Click reaction with selected 5'-azido nucleosides
Stanková Jarmila's picture

Jarmila Stanková

Master training

Supervisor:
Status: Graduated 2014 to 2016
Proteomic profile of CCRF-CEM cell line treated by 5-fluorouracil
Suchomelová Marcela's picture

Marcela Suchomelová

Master training

Status: Graduated 2015 to 2017
Characterization of vancomycin-resistant entorococci of human and animal origin
The aim of the thesis is to mapp the prevalence, phenotype and genotype of vancomycin-resistant enterococci (VRE) isolated from clinical materials of patients hospitalized in Faculty Hospital Olomouc, Czech Republic and from poultry samples obtained from the Olomouc and South Moravian Region. Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety v Bratislave (Obor Laboratórne vyšetrovacie metódy v zdravotníctve)
Světlíková Karolína's picture

Karolína Světlíková

Master training

Status: Graduated 2014 to 2016
The analysis of NOD2/CARD15 polymorphisms in patients with accute myocardial infarction
Šebrle Marek's picture

Marek Šebrle

Master training

Supervisor:
Status: Graduated 2011 to 2017
Study on metathesis triterpenoids with exoskeletarnimi double bonds
Šidová Veronika's picture

Veronika Šidová

Master training

Supervisor:
Status: Graduated 2013 to 2015
Synthesis of new cytotoxic triterpenoid derivatives using click chemistry
The main goal of this work is to introduce various substituents into the E ring of betulin and betulinic acid in order to improve the pharmacological properties and to study the mechanism of action of previously found active compounds. Main focus is on click chemistry.
Škrobánek Miroslav's picture

Miroslav Škrobánek

Master training

Supervisor:
Status: Graduated 2013 to 2014
Development of methods for the preparation of imidazo [4 ', 5': 4,5] benzo [1,2-e] [1,4] diazepin-9 (3H) -one using solid-phase
Tomanová Monika's picture

Monika Tomanová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Study of C4-arylation of 4-bromo-3,5-dinitro-1H-pyrazole via the Suzuki-Miyaura cross-coupling reaction
Trapani Patricia's picture

Patricia Trapani

Master training

Supervisor:
Status: Graduated 2016 to 2018
Synthesis of benzothiadiazepines using solid-phase synthesis
Umlaufová Eva's picture

Eva Umlaufová

Master training

Supervisor:
Status: Graduated 2016 to 2018
Preclinical evaluation of 68Ga-pyoverdines for Pseudomonas imaging
Urbanovská Radka's picture

Radka Urbanovská

Master training

Status: Graduated 2014 to 2015
The synthesis of pyrimidine derivatives as novel fluorescent labels
Vanda David's picture

David Vanda

Master training

Supervisor:
Status: Graduated 2011 to 2016
Syntéza derivátů purinu a deazapurinu a studium jejich biologických vlastností
Zálešáková Zuzana's picture

Zuzana Zálešáková

Master training

Supervisor:
Status: Graduated 2015 to 2017
Testing and optimization of new non-destructive method for determining the activity of cytidine deaminase for use of various cell lines
Zapletalová Petra's picture

Petra Zapletalová

Master training

Supervisor:
Status: Graduated 2014 to 2016
Optimalization of intact protein mass spectrometry
The main task in this thesis is to introduce and optimize methods used in non covalent and intact protein mass spectrometry. It is expected that student will get a deep knowledge about this problematics and will get used to operate with premium grade mass spectrometers.
Zbožínková Marta B.Sc.'s picture

Marta Zbožínková

Master training

Status: Graduated 2015
3D culture for the development of anticancer drugs
The aim of the study is to develop high throughput-compatible multicellular spheroid cultures of cancer cells for the screening of potential anticancer agents.
Zdráhalová Marie B.Sc.'s picture

Marie Zdráhalová

Master training

Status: Graduated 2012 to 2014
A GC×GC-TOF analysis of the human urine metabolome
This work is dealing with GC×GC TOF MS metabolomic analysis of urine sample. Silylation agent is used for derivatization. Urine sample used for optimization is analyzed by different column sets with varied polarity, width of stationary phase and internal diameter of column. BPX5/SolGel-WAX, BPX5/SLB-IL59, BPX50/SolGel-WAX, BPX50/BPX5, SolGel-WAX/BPX5, SLB-IL59/BPX50 are columns used for analysis in this work and compared. Separation success is characterized by orthogonality. Column combination BPX5/SolGel-WAX was determined as the best. This combination is used for urine sample analysis of healthy children and patients with glutaric aciduria.
Zoufalý Pavel's picture

Pavel Zoufalý

Master training

Supervisor:
Status: Graduated 2014 to 2016
Exploraton of click reaction approach in triterpenoids containing propargyl substituent
The main aim of this work is to introduce propargyl substituent to a triterpenoid molecules and optimize its reactions with azides via Huisgen cycloaddition.