Current master students

ondrej.bouska01@upol.cz's picture

Ondřej Bouška

Master training

Supervisor: Szabó Róbert PhD., PhD.
Status:
Ongoing
2018
Highthroughput screening
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Tereza Buchtová

Master training

Supervisor: Majera Dušana Ph.D.
Status:
Ongoing
2016
DNA demage responses in BRCA1 KO Sus Srofa cell line
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Filip Campsie

Master training

Supervisor: Mohelníková Duchoňová Beatrice M.D., Ph.D.
Status:
Ongoing
2017
Biomarkers of pancreas cancer
SVOČ
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Martina Drábiková

Master training

Supervisor: Soural Miroslav Ph.D.
Status:
Ongoing
2012
Synthesis of heterocyclic compound containing a sulfone or sulfonamide
Družbíková Ivana's picture

Ivana Družbíková

Master training

Supervisor: Táborská Natálie M.Sc.
Status:
Ongoing
2016
Strategy of human disease model preparation
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Barbara Duchoňová

Master training

Supervisor: Macečková Zuzana M.Sc.
Status:
Ongoing
2015 to 2017
Detection of ribosomal stress
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Dominika Flašarová

Master training

Supervisor: Mohelníková Duchoňová Beatrice M.D., Ph.D.
Status:
Ongoing
2016
KRAS signalling pathway in relation to pancreatic ductal adenocarcinoma
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Veronika Frýbortová

Master training

Supervisor: Smešný Trtková Kateřina Ph.D.
Status:
Ongoing
2016
Expression of demethylation genes from TET family proteins in samples from patients with multiple myeloma
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Gabriela Fryčová

Master training

Supervisor: Slavkovský Rastislav Ph.D.
Status:
Ongoing
2016
Methylome profiling in cancer cells for identification of bevacizumab response biomarkers
Aberrant regulation at epigenetic level can directly and/or indirectly influence the genetic integrity and gene expression pattern of cells, resulting in the development of various types of disorders, including cancer. The local hypermethylation of tumor-suppressor genes and the global hypomethylation of genomic DNA often occur in human cancers. Multiple DNA methylation changes in the cancer methylome could be associated with the acquisition of drug resistance. At our institute we are currently trying to identify new diagnostic biomarkers, which could be potentially used for better treatment personalization by bevacizumab (Avastin). Bevacizumab is a monoclonal antibody against plasma protein VEGF (vascular endothelial growth factor), which has antiangiogenic effects and is used in clinical practice for treatment of the metastatic colorectal carcinoma (CRC). We assume that genome-wide profiling of DNA methylation could help to identify undiscovered changes associated with good or bad answers to the drug and that it could also help to improve diagnostics of CRC.
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Eva Gottwaldová

Master training

Supervisor: Smešný Trtková Kateřina Ph.D.
Status:
Ongoing
2016
Polymorphism and methylation of the androgen receptor as an impact of of prostate cancer progression
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Barbora Haroková

Master training

Supervisor: Moudrý Pavel Ph.D.
Status:
Ongoing
2016
Ribosomal stress and activation of p53
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David Homola

Master training

Supervisor: Kolářová Hana Ph.D.
Status:
Ongoing
2015 to 2016
Study photo dynamic and sono dynamic responses to tumor cell lines
SVOČ
Jahodíková Kamila's picture

Kamila Jahodíková

Master training

Supervisor: Kramara Juraj Ph.D.
Status:
Ongoing
2014
The role of Aurora-A kinase in the regulation of repair crossink-hedged DNA
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Pavlína Kalábová

Master training

Supervisor: Oždian Tomáš Ph.D.
Status:
Ongoing
2014
Proteomics of the hair
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Barbora Koblihová

Master training

Supervisor: Slavkovský Rastislav Ph.D.
Status:
Ongoing
2017
Optimization of somatic mutation diagnostics in selected tumors with help of massive parallel sequencing
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Kateřina Lónová

Master training

Supervisor: Kotulová Jana M.Sc.
Status:
Ongoing
2017
Mechanisms of action of selected A3 adenosine receptor ligands
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Romana Machníková

Master training

Supervisor: Brulíková Lucie Ph.D.
Status:
Ongoing
2017
Development of novel benzoxazoles with potent antibacterial activity
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Athanasios Markos

Master training

Supervisor: Bürglová Kristýna Ph.D.
Status:
Ongoing
2014
Synthesis of new derivatives of 3-hydroxyquinoline-4 (1H) -one
Martinková Júlia's picture

Júlia Martinková

Master training

Supervisor: Jaworek Hana M.Sc.
Status:
Ongoing
2016
Forms of HPV infection in women at risk for cervical carcinoma
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Klára Míčková

Master training

Supervisor: Friedecký David Ph.D.
Status:
Ongoing
2017
Lipidomics for clinical diagnostics
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Růžena Padrtová

Master training

Supervisor: Gucký Tomáš
Status:
Ongoing
2012
Study of the synthesis and biological activity of novel derivatives of pyrazolo [1,5-a] pyrimidine as dual inhibitors of cyclin-dependent, and FLT-3 kinase
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Marek Pěntoň

Master training

Supervisor: Vojta Petr M.Sc.
Status:
Ongoing
2015
A comparative analysis of genomes Claviceps africana and Claviceps truncatispora
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Martin Pisár

Master training

Supervisor: Urban Milan Ph.D.
Status:
Ongoing
2017
Preparation of semisynthetic derivatives of betulinic acid with cytotoxic activity
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Barbora Planičková

Master training

Supervisor: Nový Zbyněk Ph.D.
Status:
Ongoing
2016
Radiolabeled agents for the diagnosis of prostate cancer
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Natália Podhorská

Master training

Supervisor: Slavkovský Rastislav Ph.D.
Status:
Ongoing
2015
Epigenetic changes detection in cancer cells
Aberrant regulation at epigenetic level can directly and/or indirectly influence the genetic integrity and gene expression pattern of cells, resulting in the development of various types of disorders, including cancer. The local hypermethylation of tumor-suppressor genes and the global hypomethylation of genomic DNA often occur in human cancers. Multiple DNA methylation changes in the cancer methylome could be associated with the acquisition of drug or ionizing radiation resistance. Cancer cell lines resistant to 2‘-deoxy 5-azacytidine (decitabine) and also radioresistant cells were prepared at our institute. Our specific aim is to assay different genome location for methylation status in resistant cancer cell lines. For this purpose, we plan to use bisulfite sequencing using multiparallel sequencing platform. Our long-term aim is to elucidate the mechanism of drug- and radioresistance in cancer cells.
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Ivana Reiterová

Master training

Supervisor: Frydrych Ivo Ph.D.
Status:
Ongoing
2015
Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors
Receptor for advanced glycation endproducts (RAGE) plays an important role in many pathological processes and thus represents potential for research and development of diagnostic and therapeutic strategies. Pyrimidine appears attractive as a template for the design of novel small-molecule RAGE inhibitors in terms of the structural simplicity and the chemical stability. The main goal of the study is to assess the contribution of RAGE in pyrimidine derivatives induced signaling response.
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Jan Skácel

Master training

Supervisor:
Status:
Ongoing
2017
Analysis of changes in TCR repertoire and cellular immune response in peripheral blood of patiens treated with ipilimumab or nivolumab for malignancy
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Dávid Švec

Master training

Supervisor: Polishchuk Pavlo Ph.D., M.Sc.
Status:
Ongoing
2016
Data-driven optimization of compound properties and exploration of a chemical space
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Patricia Trapani

Master training

Supervisor: Soural Miroslav Ph.D.
Status:
Ongoing
2016
Synthesis of benzothiadiazepines using solid-phase synthesis
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Pavel Vepřík

Master training

Supervisor: Křupková Soňa Ph.D.
Status:
Ongoing
2015
Synthesis of fluorescent labels derived from bordipyrromethenu
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Lenka Vysloužilová

Master training

Supervisor: Slavkovský Rastislav Ph.D.
Status:
Ongoing
2017
Significance assessment of gene variants identified by next-generation sequencing associated with inherited cardiomyopathies