Graduated doctoral students

Agrawal Khushboo Ph.D.'s picture

Khushboo Agrawal

Doctoral training

Status: Graduated 2010 to 2017 Specialization:
5-Azacytidine Nucleosides and their Derivatives: Molecular Hallmarks of Drug Resistance & Alternative Therapeutic Regimen
The thesis is mainly focused towards the investigation of the mechanisms of chemotherapeutic resistance to DNA methylation inhibitors. The study will aid to the understanding of the molecular basis of acquired tumor resistance and help in predicting its clinical response, as well as in designing alternative treatment regimens for overcoming resistance.
Béresová Lucie's picture

Lucie Béresová

Doctoral training

Supervisor:
Status: Graduated 2008 to 2017 Specialization:
The study of nucleic acid-protein interactions using affinity chromatography
Divoká Martina's picture

Martina Divoká

Doctoral training

Status: Graduated 2012 to 2016 Specialization: Pediatrics
101/5000 Molecular-genetic characterization of thalassemia and hemoglobin variants in the Czech and Slovak population
Flodr Patrik M.D.'s picture

Patrik Flodr

Doctoral training

Status: Graduated 2010 to 2015 Specialization:
Immunohistochemical analysis of the expression profile of specific lymphoproliferative disease and its clinical pathological significance
Gachechiladze Mariam M.D.'s picture

Mariam Gachechiladze

Doctoral training

Status: Graduated 2010 to 2015 Specialization:
Molecular markers of drug resistant non-small-cell lung cancer
Gardlo Alžběta Ph.D.'s picture

Alžběta Gardlo

Doctoral training

Supervisor:
Status: Graduated 2012 to 2016 Specialization:
Multidimensional statistical methods for analysis of human metabolome
The aim of the thesis is to study the possibility of using advanced multivariate statistical methods for statistical analysis of metabolomical data, including the use of appropriate software tools. The main part of the thesis is the application of the methodology of logratio analysis of compositional data.
Holub Dušan M.Sc.'s picture

Dušan Holub

Doctoral training

Status: Graduated 2009 to 2016 Specialization:
Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LCMS
Hepcidin, a 25 amino acid peptide, plays an important role in iron homeostasis. As such, it has potential as an indicator of any iron-related condition, such as anemia. My research focuses on the measurement of hepcidin in biological fluids to improve our understanding of iron-related disorders. A possible result of such studies could be the development of hepcidin as a tool for diagnosis and clinical management of such disorders.
Htoutou Sedlakova Miroslava's picture

Miroslava Htoutou Sedlakova

Doctoral training

Status: Graduated 2010 to 2015 Specialization:
Clinical impact of extended-spectrum beta-lactamases
The most frequent mechanism of resistance to beta-lactam antibiotics in Gram-negative bacteria is production of beta-lactamases. Those having serious clinical significance are mainly ESBL and AmpC broad-spectrum beta-lactamases and, recently, carbapenemases. For adequate antibiotic therapy of infections caused by producers of these enzymes, it is necessary to not only rapidly and correctly identify the etiological agents and their susceptibility to antibiotics but also detect the presence of these dangerous phenotypes of resistance. One of the objectives of this dissertation was to determine the sensitivity of phenotypic methods for detecting broad-spectrum beta-lactamases and carbapenemases and to select the most suitable ones for routine microbiology practice.
Jančík Sylwia Ph.D.'s picture

Sylwia Jančík

Doctoral training

Supervisor:
Status: Graduated 2009 to 2015 Specialization: Pediatrics
New strategies for genotyping of KRAs and BRAF onkomarkesrs in heterogeneous clinical tumors samples
The thesis is focused on genotyping of KRAS and BRAF in heterogeneous clinical tumor samples using different molecular genetics methods (Sanger direct sequencing, COLD-PCR, CE-IVD PCR Real-Time methods, and massively parallel sequencing).
Janíková Mária M.Sc.'s picture

Mária Janíková

Doctoral training

Status: Graduated 2011 to 2015 Specialization:
Study of new markers of multiple drug resistance with respect to lung cancer histogenesis
Konečný Petr M.Sc.'s picture

Petr Konečný

Doctoral training

Status: Graduated 2010 to 2016 Specialization:
Screening of chemical compounds´ biological activities in vitro
The thesis is focused on the identification of potentially active anticancer, antibacterial and antiparasitic compounds. Using flow cytometric evaluation provides information about cell cycle modifications after treatment with different chemical compounds and allows selection of most potent agents for further testing or synthesis of more efficient analogues.
Koudeláková Vladimíra M.Sc.'s picture

Vladimíra Koudeláková

Doctoral training

Supervisor:
Status: Graduated 2010 to 2016 Specialization:
Cytogenetic changes in patients with solid tumors
Malohlava Jakub M.Sc. Ph.D.'s picture

Jakub Malohlava

Doctoral training

Status: Graduated 2011 to 2017 Specialization:
Study of photodynamically active substances using modern microscopic techniques
The thesis is focused on the evaluation of substances used for inducing photodynamic effect in cancerous cells. The main aim is to assess the effect on mechanical properties using atomic force microscopy.
Matušková Zuzana Ph.D.'s picture

Zuzana Matušková

Doctoral training

Status: Graduated 2008 to 2015 Specialization:
Cytochromes P450 - main enzymes in drug metabolism: Study of properties of these enzymes in rat gastrointestinal tract and their influence by probiotics
The study is focused on effect of probiotics on cytochromes P450 and pharmacokinetics of concomitatntly taken drug.
Mičová Kateřina M.Sc.'s picture

Kateřina Mičová

Doctoral training

Status: Graduated 2009 to 2014 Specialization:
Significance of intracellular and plasma levels of new tyrosine kinase inhibitors
The thesis is focused on development of HPLC-MS/MS methods for determination of tyrosine kinase inhibitors imatinib, nilotinib and dasatinib used for the treatment of chronic myeloid leukemia, and also on relationship between imatinib plasma levels and treatment response.
Najdekr Lukáš M.Sc.'s picture

Lukáš Najdekr

Doctoral training

Supervisor:
Status: Graduated 2011 to 2017 Specialization:
Metabolomic tools in diagnosis of inborn errors of metabolism
The thesis is focused on untargeted metabolomics methods (high resolution exact mass spectrometry (HRMS) based methods coupled with liquid chromatography) and their development together with statistical evaluation tools. Final application will be used to study metabolomic changes in biological materials (dry blood spots, plasma, cell extracts).
Navrátilová Lucie M.Sc.'s picture

Lucie Navrátilová

Doctoral training

Status: Graduated 2015 to 2016 Specialization:
Identification and typing of nonfermenting gram-negative rods recovered from lungs of cystic fibrosis and chronic osbstructive pulmonary disease (COPD) patients
The thesis is focused on the developent of novel approaches to identification and typing of bacterial pathogens combining the technique of PCR and high-resolution melting analysis (HRMA) with the aim to translate the advances of economic and rapid molecular techniques into routine diagnostics in favor of best tailored antimicrobial therapy in chronic lung diseases.
Oždian Tomáš Ph.D.'s picture

Tomáš Oždian

Doctoral training

Status: Graduated 2009 to 2016 Specialization:
Cancer proteomics in clinical and experimental oncology
The thesis is focused on the detection possible biomarkers of cancer treatment efficiancy. Main task is to prepare database of proteomic profiles of current clinically available anticancer drugs.
Pížová Klára M.Sc.'s picture

Klára Pížová

Doctoral training

Status: Graduated 2010 to 2015 Specialization:
Effect of electromagnetic radiation and ultrasound on cell lines
The thesis is focused on in vitro testing of different sensitizers for photodynamic and sonodynamic treatment. The main goal is to identify the best sensitizer concentrations and total radiation doses and identify mechanisms of their action.
Ručil Tomáš's picture

Tomáš Ručil

Doctoral training

Supervisor:
Status: Graduated 2012 to 2017 Specialization:
Synthesis of D-Glucosamine Derivatives and their Reactivity Study at Position 1, 2, and 3
Ručilová Veronika Ph.D.'s picture

Veronika Ručilová

Doctoral training

Supervisor:
Status: Graduated 2011 to 2015 Specialization:
Development of Strategies for Solid-Phase Synthesis of Nitrogenous Heterocyclic Compounds Based on the 2- and 4-Nitrobenzenesulfonamide Chemistry
The submitted doctoral thesis deals with the development of simple procedures applicable for the preparation of libraries of selected heterocyclic compounds. In all of the introduced procedures, the immobilized 2- or 4-nitrobenzenesulfonamides were used as the key intermediates. Different scenarios have been used in which the nitrobenzenesulfonyl (Nos) group was applied (1) only as a protective/activating group for Fukuyama selective monoalkylation followed by the cleavage of the sulfonamide scaffold, (2) as a building block after previous Fukuyma alkylation, or (3) as a building block without application of Fukuyama alkylation. The key intermediates were further modified and converted to the target products under different cyclization conditions. During our long-term research we have developed high-throughput solid-phase syntheses of various heterocyclic compounds involving six types of different scaffolds.
Řehulka Jiří M.Sc.'s picture

Jiří Řehulka

Doctoral training

Status: Graduated 2010 to 2017 Specialization:
Mitochondria as a therapeutic target in cancer
Mitochondria are organelles involved in cellular energy metabolism. This aspect of the cell-physiology is often altered during neoplastic transformation/carcinogenesis. For this reason, mitochondria constitute potential targets in cancer therapy. My work focuses on the anti-cancer activity of novel derivatives of betulinic acid in the context of drug-discovery.
Sulovská Lucie's picture

Lucie Sulovská

Doctoral training

Status: Graduated 2012 to 2016 Specialization: Pediatrics
The importance of hepcidin testing in selected congenital anemias in childhood and in blood donors
Šimková Dana M.Sc.'s picture

Dana Šimková

Doctoral training

Supervisor:
Status: Graduated 2009 to 2016 Specialization:
Study of invasive growth and its blocation possibilities in breast and prostate cancer
Thesis is focused on an identification of asporin‘s (protein interacting with extracellular matrix) role in motility and invasiveness of model cell lines. The main goal is to determine if asporin could be considered as a marker of tumor metastatic behaviour.
Šváchová Michaela M.Sc.'s picture

Michaela Šváchová

Doctoral training

Supervisor:
Status: Graduated 2010 to 2015 Specialization:
Importance of molecular markers for cancer diagnostics
The thesis is focused on the detection of cancer associated markers. Emphasis is on importance of polymerase chain reaction based gene rearrangements in the diagnosis of lymphoproliferative disorders in biopsy samples. These results have confirmed that the PCR-based analysis is suitable as a routine method and is helpful in establishing a diagnosis in morphologically unclear cases.
Uvírová Magdalena Ph.D.'s picture

Magdalena Uvírová

Doctoral training

Status: Graduated 2011 to 2016 Specialization: Pediatrics
Molecular genetic studies of selected solid tumors
Zapletalová Hana's picture

Hana Zapletalová

Doctoral training

Status: Graduated 2007 to 2016 Specialization:
Study of physical and chemical properties of biological materials through microscopic methods
Zezulová Michaela's picture

Michaela Zezulová

Doctoral training

Status: Graduated 2012 to 2016 Specialization:
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