Current doctoral students

Ambrožová Nikola's picture

Nikola Ambrožová

Doctoral training

Supervisor:
Galandáková Adéla Ph.D.
Status: Ongoing
2012
Specialization:
The study of the physical damage of skin cells
Annadurai Narendran M.Sc.'s picture

Narendran Annadurai

Doctoral training

Supervisor:
Das Viswanath M.Sc., Ph.D.
Status: Ongoing
2015
Specialization:
Kinase inhibitors in the treatment of neurodegenerative diseases
My Research thesis is focused on the identification of potential inhibitors of kinases involved in the tau hyperphosphorylation mediated tau aggregation induced tauopathy in neurodegenerative diseases, in particular Alzheimer’s disease (AD). The study will shed further insight into the role of disease-specific kinases in the pathogenesis of AD. The study involves screening of small molecule inhibitors of kinases as well as tau aggregation and their characterization in in vitro and in vivo models of AD.
Béresová Lucie's picture

Lucie Béresová

Doctoral training

Supervisor:
Status: Ongoing
2008
Specialization:
The study of nucleic acid-protein interactions using affinity chromatography
Boháčová Marie's picture

Marie Boháčová

Doctoral training

Supervisor:
Hradil Pavel
Status: Ongoing
2014
Specialization:
Synthesis of new biologically active substances from the group of 2-substituted 3-hydroxy-4 (1H) -quinolones
Borková Lucie M.Sc.'s picture

Lucie Borková

Doctoral training

Supervisor:
Urban Milan Ph.D.
Status: Ongoing
2014
Specialization:
Modification of triterpenes with the use of transition metal catalyzed reactions and nucleophilic substitution
In this work, a larger study of transition metal catalyzed reaaction of triterpenes should be studied in order to find a new approach for a preparation of novel derivatives with high cytotoxic activity and favorable pharmacological properties.
Crlíková Hana's picture

Hana Crlíková

Doctoral training

Supervisor:
Bartoň Tománková Kateřina Ph.D.
Status: Ongoing
2016
Specialization:
Use of nanomaterials for targeted delivery of drug
Dostál Zdeněk M.Sc.'s picture

Zdeněk Dostál

Doctoral training

Supervisor:
Modrianský Martin Ph.D.
Status: Ongoing
2013
Specialization:
Modulation of expression of microRNAs flavonoids
Fialová Barbora M.Sc.'s picture

Barbora Fialová

Doctoral training

Supervisor:
Smešný Trtková Kateřina Ph.D.
Status: Ongoing
2009
Specialization:
Implications of epigenetic changes in cells derived from prostate cancer
The thesis is focused on a study of DNA methyltransferase (5-aza-2´-deoxycytidine, Aza-dC) and histone deacetylase (sodium butyrate, NaB) inhibitors effects on prostate cancer cells with modified expression of the androgen receptor gene. The androgen-independent human prostate cancer cell lines PC3 (without a functional androgen receptor) and DU145 (with strongly limited expression due to methylation of the androgen receptor gene) are used. The methodology is based on PCR of bisulfite-modified DNA and RT-PCR with bisulfite-sequencing.
Flodrová Pavla's picture

Pavla Flodrová

Doctoral training

Supervisor:
Smešný Trtková Kateřina Ph.D.
Status: Ongoing
2011
Specialization:
Study and control options molecular mechanisms in hematologic malignancies
Gamratová Mária's picture

Mária Gamratová

Doctoral training

Supervisor:
Brychtová Světlana M.D., Ph.D.
Status: Ongoing
2016
Specialization: Pathological anatomy and forensic medicine
The role of cancer microenvironment in prognosis of Hodgkin lymfomas
Grešáková Veronika's picture

Veronika Grešáková

Doctoral training

Supervisor:
Status: Ongoing
2014
Specialization:
Functional characterization of FAM208a
Hakobjanyan Anahit's picture

Anahit Hakobjanyan

Doctoral training

Supervisor:
Petřek Martin M.D., CSc.
Status: Ongoing
2010
Specialization:
Expression and regulation of cytokines or signaling molecules at the interface of bone and joint replacement: a contribution to the immunopathogenesis osteolysis/ periprosthetic infection
Hodoň Jiří's picture

Jiří Hodoň

Doctoral training

Supervisor:
Urban Milan Ph.D.
Status: Ongoing
2017
Specialization:
Cytotoxic active triterpenes and their mechanism of action
Holoubek Martin M.Sc.'s picture

Martin Holoubek

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2013 to 2018
Specialization:
Horák Radim's picture

Radim Horák

Doctoral training

Supervisor:
Hradil Pavel
Status: Ongoing
2013
Specialization:
Synthesis of 2-alkyl-3-hydroxyquinoline-4 (1H) -one
Hošíková Barbora M.Sc.'s picture

Barbora Hošíková

Doctoral training

Supervisor:
Binder Svatopluk Ph.D.
Status: Ongoing
2013
Specialization:
In vitro study of the effect of the photosensitive substance on the tumor cell lines
This study deals with utilization of newly synthetised photosensitizers chemically clasified as phthalocyanines in photodynamic therapy.The photosensitizers are tested in vitro on tumor cell line – HeLa (cervical cancer cells) and non-tumor cell line NIH3T3 (mouse fibroblasts). A main goal is to find the photosensitizer causing the highest phototoxic effect on the tumor cells with minimal side effects.
Houdová Megová Magdalena M.Sc.'s picture

Magdalena Houdová Megová

Doctoral training

Supervisor:
Trojanec Radek Ph.D.
Status: Ongoing
2010
Specialization:
Cytogenetics changes in solid tumors
The thesis is focused on the identification of molecular and genetic changes in solid tumors focusing on glial tumors especially on a group of recurrent glioblastoma. The main goal is to identify molecular and genetic aberrations harboured by glial tumors and selected these which are responsible for glial tumor progression and recurrence.
Hrčková-Drozdová Denisa's picture

Denisa Hrčková-Drozdová

Doctoral training

Supervisor:
Smešný Trtková Kateřina Ph.D.
Status: Ongoing
2016
Specialization: Medical biology
Effect of histone deacetylase inhibitors on apoptosis and proliferative activity of cancer cells
Hušková Zlata B.Sc.'s picture

Zlata Hušková

Doctoral training

Supervisor:
Steigerová Jana Ph.D.
Status: Ongoing
2015
Specialization:
Molecular mechanisms of action of plant steroids on tumor cells
Chabroňová Alžběta's picture

Alžběta Chabroňová

Doctoral training

Supervisor:
Navrátilová Zdenka Ph.D.
Status: Ongoing
2015
Specialization: Physiology and pathophysiology
Exosomal miRNAs in chronic obstructive lung disease
This study will be focused on identifying mechanisms of post-transcriptional regulation in COPD pathogenesis by measuring expression of selected miRNAs and determining differentially expressed miRNAs in patients vs controls.
Chromá Katarína M.Sc.'s picture

Katarína Chromá

Doctoral training

Supervisor:
Kramara Juraj Ph.D.
Status: Ongoing
2012
Specialization:
Using novel anti-cancer agents in elucidation of DNA damage response (DDR) mechanisms and their role in onset of cancer
The thesis is centered on cellular responses, termed DNA damage response (DDR) to DNA double-strand breaks, presumably the most deleterious lesions affecting DNA. The aim of the thesis is to shed more light on certain mechanistic aspects of the DDR. To this end, several chemical inhibitors interfering with different key steps of the DDR are utilized. Apart from deciphering the underlying mechanisms, this approach might lead to new diagnostic and therapeutic approaches.
Jáčová Jaroslava M.Sc.'s picture

Jaroslava Jáčová

Doctoral training

Supervisor:
Adam Tomáš Ph.D.
Status: Ongoing
2013
Specialization:
Metabolomic GC×GC-TOF MS analysis of biofluids
The thesis is focused on metabolomic analysis of biofluids, using comprehesnive two-dimensional gas chromatography coupled with time of flight mass spectrometry (GC×GC-TOF MS). The optimal column combination suitable for given biofluid has been evaluated, GC×GC TOF-MS analysis has been optimized, separation efficiency has been determined, data processing method has been developed.
Jakoubková Martina M.Sc's picture

Martina Jakoubková

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2015
Specialization:
Expression profiling effect of anticancer drugs
Jaworek Hana M.Sc.'s picture

Hana Jaworek

Doctoral training

Supervisor:
Trojanec Radek Ph.D.
Status: Ongoing
2012
Specialization:
Detection of molecular cytogenetic abnormalities and their significance in predicting prognosis and treatment response in cancer
The thesis is focused on influence of HPV infection on fertility and cancer development. HPV DNA is detected by PCR based diagnostics and in situ hybridisation. The main goal is to determine an influence of HPV on fertility and cancer development.
Jedináková Petra M.Sc.'s picture

Petra Jedináková

Doctoral training

Supervisor:
Hlaváč Jan Ph.D.
Status: Ongoing
2013
Specialization:
Preparation of compounds for copper free click reactions
Jiravová Jana M.Sc.'s picture

Jana Jiravová

Doctoral training

Supervisor:
Bartoň Tománková Kateřina Ph.D.
Status: Ongoing
2013
Specialization:
The study of nanomaterials using modern microscopic techniques
The thesis is focused on the characterisation of nanoparticles properties and detection effect of nanoparticles on biological systems included tumor and non-tumor cell lines. For detection of nanoparticles are used modern microscopic techniques (e.g. atomic force microscopy, Raman spectroscopy, confocal and electron microscopy). Nanoparticles are massively used in daily life, so it is important to know their properties.
Juráňová Jana M.Sc.'s picture

Jana Juráňová

Doctoral training

Supervisor:
Franková Jana Ph.D.
Status: Ongoing
2013
Specialization:
The mechanism of wound healing
Karas Daniel M.Sc.'s picture

Daniel Karas

Doctoral training

Supervisor:
Ulrichová Jitka CSc.
Status: Ongoing
2012
Specialization:
Studying the impact of natural compounds on angiogenesis in vitro
Karlíková Radana M.Sc.'s picture

Radana Karlíková

Doctoral training

Supervisor:
Friedecký David Ph.D.
Status: Ongoing
2013
Specialization:
Study of patobiochemistry of inherited metabolic disorders by metabolomic approach
The thesis is focused on the targeted and untargeted metabolomic analysis of selected diseases by liquid chromatography coupled with tandem mass spectrometry and high resolution mass spectrometry. The main goal is the identification of biomarkers and understanding changes in metablolic pathways important for patobiochemistry of inherited disorders.
Kocmanová Leona's picture

Leona Kocmanová

Doctoral training

Supervisor:
Hlaváč Jan Ph.D.
Status: Ongoing
2015
Specialization:
Stereoselective synthesis on solid support
Kocourková Lenka M.Sc.'s picture

Lenka Kocourková

Doctoral training

Supervisor:
Smešný Trtková Kateřina Ph.D.
Status: Ongoing
2009
Specialization:
Effect of coregulators on the androgen receptor activity in cells derived from prostate cancer after their treatment with histone deacetylase inhibitor
The thesis is focused on the detection of coregulator expressions in cancer and normal prostate cells. Coregulators, coactivators as well as coregulators, play an important role in androgen receptor-mediated progression of the prostate cancer. There is a competition between coactivators and corepressors for binding on the androgen receptor and therefore, the changes and the expression ratio between could be important for prostate cancer growth and progression. We focus on two regulators: SMRT (silencing mediator for retinoid and thyroid hormone receptors) as corepressor, and p300 as coactivator.
marketa.koleckova01@upol.cz's picture

Markéta Kolečková

Doctoral training

Supervisor:
Kolář Zdeněk M.D., CSc.
Status: Ongoing
2016
Specialization: Pathological anatomy and forensic medicine
New diagnostic biomarkers and tumor progression
Kotková Lucie's picture

Lucie Kotková

Doctoral training

Supervisor:
Drábek Jiří Ph.D.
Status: Ongoing
2017
Specialization:
Genetic and Epigenetic Biomarkers in cancer
Kotulová Jana M.Sc.'s picture

Jana Kotulová

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Adenosine receptor inhibitors, the development and optimization
Adenosine receptors are involved in several cellular processes and can play significant role in development of various diseases, including cancer. The aim of the thesis is to study the role of adenosine receptors in cell physiology as well as in pathological state. This work is focused on screening of potential ligands of adenosine receptors and characterization of their molecular interactions using high-throughput screening approach and further validation by methods of molecular biology. Novel potent inhibitors can be beneficial for cancer therapy in the future.
stepan.kouril01@upol.cz's picture

Štěpán Kouřil

Doctoral training

Supervisor:
Friedecký David Ph.D.
Status: Ongoing
2017
Specialization: Medical chemistry and clinical biochemistry
Lipidomic analysis of biological samples by HR-MS
Krajčovičová Soňa's picture

Soňa Krajčovičová

Doctoral training

Supervisor:
Soural Miroslav Ph.D.
Status: Ongoing
2015
Specialization:
Solid-phase synthesis of heterocyclic compounds and study of their biological properties
This work will be focused on development of synthetic pathways applicable for high-throughput synthesis of organic compounds containing heterocyclic moiety and further evaluation of their biological properties.
Králová Petra's picture

Petra Králová

Doctoral training

Supervisor:
Soural Miroslav Ph.D.
Status: Ongoing
2016
Specialization:
Developmet of methods of preparation of heterocyclic compounds with potential biological activity with use of solid-phase synthesis
Krasulová Kristýna's picture

Kristýna Krasulová

Doctoral training

Supervisor:
Anzenbacher Pavel D.Sc.
Status: Ongoing
2013
Specialization:
Studium interakcí léčiv s enzymy metabolismu cizorodých látek.
Krátká Leona's picture

Leona Krátká

Doctoral training

Supervisor:
Hlaváč Jan Ph.D.
Status: Ongoing
2015
Specialization: Organic chemistry
Stereoselective synthesis on solid support
Kubíčková Agáta's picture

Agáta Kubíčková

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2016
Specialization: Oncology
Cell models for optical screening of biologically active compounds
Lemstrová Radmila's picture

Radmila Lemstrová

Doctoral training

Supervisor:
Mohelníková Duchoňová Beatrice M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Prognostic and predictive factors for pancreatic cancer
Lukešová Lucie's picture

Lucie Lukešová

Doctoral training

Supervisor:
Vrána David Ph.D.
Status: Ongoing
2012
Specialization:
Prognostic and predictive factors for selected cancers
Lužná Petra's picture

Petra Lužná

Doctoral training

Supervisor:
Smešný Trtková Kateřina Ph.D.
Status: Ongoing
2014
Specialization:
Methylation status in patients with multiple myeloma
Macečková Zuzana M.Sc.'s picture

Zuzana Macečková

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Molecular pathology of Diamond-Blackfan anemia
Diamon-Blacfan anemia is a rare congenital red cell aplasia, often associated with congenital malformations, particularly of upper limbs and craniofacial region. As a cause, mutations in genes for ribosomal proteins have been reported in approximately 50% of the cases. Mutations in ribosomal proteins lead to defects during ribosome biogenesis and thus ribosome stress, which in turn leads to cell cycle arrest or apoptosis in erythroid progenitors.In my study, I focus on discovering and validation of new possible molecular causes of Diamond-Blackfan anemia and other ribosomopathies by NGS approach followed by functional studies of chosen genes.
Mádrová Lucie M.Sc's picture

Lucie Mádrová

Doctoral training

Supervisor:
Adam Tomáš Ph.D.
Status: Ongoing
2015
Specialization:
Study of the effect of selected cancerostatics on the cell metabolome
The thesis is focused on the development of both targeted and untargeted metabolomics methods (liquid chromatography coupled with high resolution mass spectrometry) for the study of the effects of various anticancer drugs on model cell lines. The main goal is to quantitatively analyse changes in metabolome’s composition for the comprehensive characterization of metabolic networks.
Malá Zuzana's picture

Zuzana Malá

Doctoral training

Supervisor:
Kolářová Hana Ph.D.
Status: Ongoing
2015
Specialization:
Nanomaterials and the study of cell damage fluorescence methods
The thesis is focused on the study of effect of various porphyrin and phtalocyanin photosensitizers during different light intensity on cell and bacterial lines using fluorescent, molecular and microscopis methods. Further the thesis is focused on the characterisation of nanoparticles properties combinated with photodynamic therapy.
Malina Lukáš M.Sc.'s picture

Lukáš Malina

Doctoral training

Supervisor:
Bartoň Tománková Kateřina Ph.D.
Status: Ongoing
2013
Specialization:
Study of cell destruction using physical and chemical methods
The thesis is focused on the study of effect of various porphyrin and phtalocyanin photosensitizers during different light intensity on G361 (human skin melanoma) and NIH3T3 (mouse fibroblasts) cell lines using fluorescent, molecular and microscopic methods. Main aim is on the dependence of photodynamic therapy on photosensitizer type, its concentration and light doses on tumorous and non-tumorous lines to choose best fitting photosensitizer.
martina.matejkova01@upol.cz's picture

Martina Matějková

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2016
Specialization: Oncology
Expression profiling effects of anticancer drugs
Matveieva Mariia's picture

Mariia Matveieva

Doctoral training

Supervisor:
Polishchuk Pavlo Ph.D., M.Sc.
Status: Ongoing
2016
Specialization: Pediatrics
Automatic mining of relationships between structure and activity in chemical databases
The thesis is focused on the development of methods and tools for mining valuable structural features of compounds in chemical databases. Those methods are being developed with the main goal to explain observed structure-activity relationships and to design new molecules with improved properties.
Matzenauer Marcel's picture

Marcel Matzenauer

Doctoral training

Supervisor:
Vrána David Ph.D.
Status: Ongoing
2014
Specialization: Oncology
Evaluation of the effectiveness and toxicity of stereotactic radiotherapy
Medvedíková Martina M.Sc.'s picture

Martina Medvedíková

Doctoral training

Supervisor:
Mašek Vlastimil Ph.D.
Status: Ongoing
2013
Specialization:
Study of interaction of biologically active small molecules with selected target macromolecules
The thesis is focused on the study of the interaction potential anticancer drugs with target macromolecules (DNA, proteins). These interactions are analyzed using various methods, such as isothermal titration calorimetry, confocal Raman microscopy and molecular biology methods.
Mičková Alena's picture

Alena Mičková

Doctoral training

Supervisor:
Bouchal Jan Ph.D.
Status: Ongoing
2014
Specialization:
Monitoring characteristics of tumor stem cells from prostate cancer
Michálek Jaroslav's picture

Jaroslav Michálek

Doctoral training

Supervisor:
Brychtová Světlana M.D., Ph.D.
Status: Ongoing
2012
Specialization:
Molecular aspects of atherosclerosis (focusing on microRNA)
Novosadová Eva's picture

Eva Novosadová

Doctoral training

Supervisor:
Petřek Martin M.D., CSc.
Status: Ongoing
2014
Specialization:
Role of RBPs (RNA- binding proteins) in regulation of immune reactions
In this thesis will be studied RNA- binding proteins on their expression level. Further will be investigated their possible role of biomarkers in patients with inflammatory lung diseases.
Ondra Martin's picture

Martin Ondra

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2017
Specialization:
Role of ribosomal proteins and ribosomal stress in case of DNA damage
robert.ondrussek@upol.cz's picture

Róbert Ondruššek

Doctoral training

Supervisor:
Brychtová Světlana M.D., Ph.D.
Status: Ongoing
2016
Specialization: Pathological anatomy and forensic medicine
The role of cancer microenvironment in cancer prognosis
Pastorková Zuzana's picture

Zuzana Pastorková

Doctoral training

Supervisor:
Škarda Jozef M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Influence of microRNA to metastasis
Petráček Marek M.Sc.'s picture

Marek Petráček

Doctoral training

Supervisor:
Hlaváč Jan Ph.D.
Status: Ongoing
2012
Specialization:
Synthesis derivatives of 3-hydroxy-quinolin-4 (1H)-ones and study of their biological and fluorescence properties
2-substituted 3-hydroxyquinoline-4-(1H)-ones (3HQs) is a substance with very promising biological and fluorescent properties. But 3HQs have some negative characteristics. This includes especially low solubility in polar solvents and low stability under physiological pH conditions. Modification that solves the problem is targeted binding hydrophilic groups on the nitrogen atom at position 1. Second possibility is modifying a basic skeleton 3HQs. We create new skeletons with similar structure. Recently, our attention is focused on reducing 3HQs. We used catalytic hydrogenation.
ivana.petrovicova01@upol.cz's picture

Ivana Petrovičová

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2017
Specialization: Pediatrics
Detection of molecular cytogenetic abnormalities
Pokorný Jan's picture

Jan Pokorný

Doctoral training

Supervisor:
Urban Milan Ph.D.
Status: Ongoing
2015
Specialization:
Modifications of double bonds in triterpenes with antitumor activity
In this work, double bond of betulin, betulinic acid and other cytotoxic triterpenes will be modified by various methods. First method will be based on transition metal catalyzed crosscoupling reactions, of triterpenic boronic acids with a variety of other molecules. Second, aldehyde will be prepared in the neighborhood of the double bond and it will be condensed with a number of organic hydrazines, hydrazones, amines etc.
Pola Martin's picture

Martin Pola

Doctoral training

Supervisor:
Bajgar Robert M.D., Ph.D.
Status: Ongoing
2015
Specialization:
The role of oxygen in the effectiveness of photodynamic therapy on cellular models in the presence of sensitizers
Porubský Martin's picture

Martin Porubský

Doctoral training

Supervisor:
Hlaváč Jan Ph.D.
Status: Ongoing
2015
Specialization:
Preparation and study of new fluorescent systems for intracellular imaging
Potočková Jana M.Sc.'s picture

Jana Potočková

Doctoral training

Supervisor:
Trojanec Radek Ph.D.
Status: Ongoing
2014
Specialization:
The importance of cytogenetic changes in the treatment and prognosis of oncologic diseases
The thesis is mainly focused towards the investigation of cytogenetic changes in solid tumors by FISH method. One of the aimes was to reveal several potential markers which could have an impact on the prediction of treatment response and prognosis of the disease, in the first part of the small cell lung cancer.
Prokopová Andrea M.Sc.'s picture

Andrea Prokopová

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2009
Specialization:
Detection and clinical importance of minimal residual disease in solid tumours
The thesis is focused on the detection of circulating tumour cells by qRT-PCR and the clinical importance of their presence in solid tumours, especially in lung, breast, pancreatic and colorectal cancer patients. The main goal is to identify patients with high risk of disease recurrence and in need of adjuvant therapy.
Purová Soňa's picture

Soňa Purová

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2012
Specialization:
julie.rendlova01@upol.cz's picture

Julie Rendlová

Doctoral training

Supervisor:
Hron Karel Ph.D.
Status: Ongoing
2017
Specialization: Applied mathematics
Advanced methods of compositional data analysis
Roubalová Lenka M.Sc.'s picture

Lenka Roubalová

Doctoral training

Supervisor:
Vrba Jiří Ph.D.
Status: Ongoing
2013
Specialization:
Molecular mechanisms of the protective effect of natural substances
Rylová Gabriela M.Sc.'s picture

Gabriela Rylová

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2009
Specialization:
Identification of molecular targets of anticancer drugs by proteomic methods
The thesis is focused on the identification of molecular targets and mechanism of action of quinolone derivatives with anticancer properties. The method used for this purpose is affinity purification coupled to mass spectrometry. Obtained data will be used for structure optimization of these potential anticancer compounds.
Řeháčková Lenka's picture

Lenka Řeháčková

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2015
Specialization:
Mechanism of multidrug resistance (MDR) in cancer cells
Řehulka Jiří M.Sc.'s picture

Jiří Řehulka

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2010
Specialization:
Mitochondria as a therapeutic target in cancer
Mitochondria are organelles involved in cellular energy metabolism. This aspect of the cell-physiology is often altered during neoplastic transformation/carcinogenesis. For this reason, mitochondria constitute potential targets in cancer therapy. My work focuses on the anti-cancer activity of novel derivatives of betulinic acid in the context of drug-discovery.
Řehulková Alona's picture

Alona Řehulková

Doctoral training

Supervisor:
Srovnal Josef M.D., Ph.D.
Status: Ongoing
2015
Specialization:
Prognostic and predictive factors in solid tumors
Sikorová Kateřina B.Sc.'s picture

Kateřina Sikorová

Doctoral training

Supervisor:
Petřek Martin M.D., CSc.
Status: Ongoing
2015
Specialization:
Genetic variability of bio markers of inflammation in patients with early manifestation of coronary artery disease
Slavík Hanuš M.Sc.'s picture

Hanuš Slavík

Doctoral training

Supervisor:
Srovnal Josef M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Minimal residual disease in solid cancers
The main goal of this thesis is to discover new biomarkers on the level of RNA. These biomarkers can be tested for usage in predictive and prognostic medicine and they can help in early diagnostic or in postoperative identification of the risk of recurrence. The methods used for this purpose are RT-qRCR and microarray assays (cytoscan).
Sněhota Martin's picture

Martin Sněhota

Doctoral training

Supervisor:
Status: Ongoing
2016
Specialization: Medical biophysics
Objectification of quality of ultrasound imaging
Sťahelová Anna M.Sc.'s picture

Anna Sťahelová

Doctoral training

Supervisor:
Mrázek František M.D., Ph.D.
Status: Ongoing
2010
Specialization:
Genetic factors in complex diseases with inflammatory compound in pathogenesis
The thesis is focused on the genetic association studies (GAS) in complex diseases. GAS use the comparison of genetic markers (Single Nucleotide Polymorphisms or Copy Number Variations) between the patients with complex diseases and healthy controls. The main goal is to detect susceptibility genes responsible for heritable component of complex diseases.
Stanková Jarmila's picture

Jarmila Stanková

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2016
Specialization:
Cytotoxic drugs molecular target identification by methods of cell biology and proteomics
Molecular target identification of biologically active molecules is a key factor facilitating rational design and preclinical development of potential drugs. Methods of cellular biology, chemical proteomics and mass spectrometry are developed and used for its purposes.
Světlíková Karolína's picture

Karolína Světlíková

Doctoral training

Supervisor:
Petřková Jana Ph.D.
Status: Ongoing
2016
Specialization:
Pathophysiology of selected internal diseases
Škrott Zdeněk M.Sc.'s picture

Zdeněk Škrott

Doctoral training

Supervisor:
Mistrík Martin Ph.D.
Status: Ongoing
2014
Specialization:
The role of the ubiquitin-proteasome system in tumorigenesis and cancer treatment
Regulated protein degradation is mediated by ubiquitin-proteasome system. Inhibition of proteasome proteolytic activity is a promising approach in cancer therapy with first-in-class drug bortezomib approved for the treatment of patients with multiple myeloma. Since ubiquitination regulates not only protein degradation but also wide variety of cellular signaling pathways, this new approach might bring new drugs with better efficacy and safety profiles.
Šlachtová Veronika's picture

Veronika Šlachtová

Doctoral training

Supervisor:
Brulíková Lucie Ph.D.
Status: Ongoing
2017
Specialization: Organic chemistry
Design and synthesis of compounds with potential anti-TB properties
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Alena Špičáková

Doctoral training

Supervisor:
Anzenbacher Pavel D.Sc.
Status: Ongoing
2012
Specialization: Medical pharmacology
Drug interactions with nutraceuticals level metabolism
Šporiková (Crlíková) Zuzana M.Sc.'s picture

Zuzana Šporiková (Crlíková)

Doctoral training

Supervisor:
Trojanec Radek Ph.D.
Status: Ongoing
2013
Specialization:
Cytogenetics changes in solid tumors
The thesis is focused on the identification of molecular and genetic changes in solid tumors focusing on glial tumors especially on a group of recurrent glioblastoma. The main goal is to identify molecular and genetic aberrations which are responsible for glioblastoma progression and recurrence by comprehensive, complementary molecular genetic methods and high-throughput technologies.
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Nikola Štefelová

Doctoral training

Supervisor:
Hron Karel Ph.D.
Status: Ongoing
Specialization: Applied mathematics
Compositional approach in the analysis of biomolecular data
Táborská Natálie M.Sc.'s picture

Natálie Táborská

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2014
Specialization:
High throughput sequencing methods in biomarker identification and validation
High throughput sequencing is rapidly improving in its quality, speed and cost. This scientific approach increases our ability to characterise diseases at the genomic, transcriptomic and epigenetic levels. The aim of the thesis is to use this technique for studying cells under ribosomal stress. The work is focused on the identification and validation of biomarkers that are in connection with ribosomal stress caused diseases.
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Zsofia Turi

Doctoral training

Supervisor:
Moudrý Pavel Ph.D.
Status: Ongoing
2014
Specialization:
Replication stress induced cellular senescence in primary fibroblast cell lines
Cellular senescence is defined as a permanent cell cycle checkpoint arrest. The two tumor suppressor proteins indicated in cellular senescence, p16INK4a and p14ARF are encoded on the same locus, although activated independently from each other, as a consequence of various stresses. My study focuses on the identification of the kinetics and mode of their activation upon replication stress.
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Cheng Tzu-Hsuan

Doctoral training

Supervisor:
Drábek Jiří Ph.D.
Status: Ongoing
2016
Specialization:
Cell line authentication using PCR High Resolution Melting Analysis
Podílet se na optimalizaci a vývoji metody pro autentizaci buněčných linií, která bude mít stejnou rozlišovací schopnost jako DNA profilování pomocí genotypizace mikrosatelitů, ale bude využívat jen real-time PCR cyklér bez nutnosti detekčního kroku kapilární elektroforézou
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Irena Urbanovská

Doctoral training

Supervisor:
Drábek Jiří Ph.D.
Status: Ongoing
2009
Specialization:
Genetic and epigenetic characterization of patients with glioblastoma
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Jan Václavík

Doctoral training

Supervisor:
Adam Tomáš Ph.D.
Status: Ongoing
2013
Specialization:
Metabolomic tools for diagnosis of inherited metabolic disorders
Inherited metabolic disorders of purine and pyrimidine (PP) metabolism exhibit broad neurological, hematological, immunological and renal manifestations. They are characterized by increased concentrations of PP metabolites in body fluids caused by abnormal or missing activity of particular enzyme which is involved in their metabolism. Liquid chromatography coupled to tandem mass spectrometry (LC‐MS/MS) is method of choice in the last 15 years for diagnoses of PP metabolic disorders. Due to instrumental price drop high‐resolution mass spectrometry (HRMS) is starting to be increasingly used in clinical laboratories. The aim of this work is to compare diagnostic efficacy of these two approaches.
Václavková Jana M.Sc.'s picture

Jana Václavková

Doctoral training

Supervisor:
Džubák Petr M.D., Ph.D.
Status: Ongoing
2013
Specialization:
Identification of mechanisms of action of molecules with anticancer effect
The thesis is focused on optimization of the method for identifying cellular targets of anticancer drugs. The aim of the work is to optimize affinity purification using streptavidin coated plates. Next the new drugs will be tested to find their molecular target and the validation studies will be performed.
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Zuzana Valachová

Doctoral training

Supervisor:
Vrána David Ph.D.
Status: Ongoing
2014
Specialization:
Predictive and prognostic factors in breast cancer
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David Vanda

Doctoral training

Supervisor:
Soural Miroslav Ph.D.
Status: Ongoing
2016
Specialization: Medical chemistry
Synthesis of heterocyclic compounds as ligands of serotonine receptors and phosphodiesterases
Vanek Peter M.Sc.'s picture

Peter Vanek

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Factors affecting the participation of individuals in cancer screening programs.
The reasons that make patients adhere, or not to, cancer screening guidelines are not only related to individual and health characteristics but are also placed in a wider social and cultural context. The aim of our study is to explore the associations of individual-level social aspects with cancer screening and the knowledge for the existence of relevant screening programs to identify major barriers in participation.
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Renata Večeřová

Doctoral training

Supervisor:
Kolář Milan M.D., Ph.D.
Status: Ongoing
2012
Specialization:
Možnosti testování antimikrobní aktivity stávajících a nově vyvíjených látek
Cílem práce je definovat antimikrobní účinky nových látek, především nanočástic stříbra. Bude testován účinek na standardní referenční bakteriální kmeny, multirezistentní bakterie a na vybrané kvasinky. Na základě výsledků budou analyzovány potencionální praktické možnosti těchto látek.
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Eva Veselá

Doctoral training

Supervisor:
Mistrík Martin Ph.D.
Status: Ongoing
2011
Specialization:
Application of quantitative microscopy analysis of DNA damage for study of cell response to γ-irradiation and radiomimetic compounds in different genetic backrounds.<br /><br /> Supervisor 2011-2015 doc. RNDr. Radek Vrtěl, Ph.D.
Vidlařová Monika M.Sc.'s picture

Monika Vidlařová

Doctoral training

Supervisor:
Srovnal Josef M.D., Ph.D.
Status: Ongoing
2014
Specialization:
Detection and clinical importance of circulating tumor cells in solid tumours
The thesis is focused on the detection of circulating tumour cells (CTCs) by different approaches and the clinical importance of their presence in solid tumours, especially in lung, pancreatic and colorectal cancer patients. The main goal is to identify patients with high risk of disease recurrence and in need of adjuvant therapy. The second goal is to participate in the research and development of novel methods of CTCs detection and characterization.
Vojta Petr M.Sc.'s picture

Petr Vojta

Doctoral training

Supervisor:
Hajdúch Marián M.D., Ph.D.
Status: Ongoing
2009
Specialization:
Molecular biological methods of preimplantation diagnosis
Vrobel Ivo M.Sc.'s picture

Ivo Vrobel

Doctoral training

Supervisor:
Friedecký David Ph.D.
Status: Ongoing
2013
Specialization:
Influence of certain cancerostatics on the cell metabolome
The influence of chosen cancerostatics (TKI, MTX, …) on the cell metabolome is evaluated using LC-MS. The main goal is to find new biomarkers of the treatment response and new drug metabolites using targeted and untargeted metabolomic approach.
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Tomáš Zemánek

Doctoral training

Supervisor:
Mohelníková Duchoňová Beatrice M.D., Ph.D.
Status: Ongoing
2017
Specialization: Oncology
Prognostic and predictive markers of pancreatic carcinoma
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Ludmila Žárská

Doctoral training

Supervisor:
Kolářová Hana Ph.D.
Status: Ongoing
2015
Specialization:
Photodynamically active substances possibility of their use for photodynamic therapy of tumors
The thesis is focused on the study of effect of various porphyrin and phtalocyanin photosensitizers during different light intensity on cell lines using molecular and microscopic methods.
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Vladimír Židlík

Doctoral training

Supervisor:
Brychtová Světlana M.D., Ph.D.
Status: Ongoing
2015
Specialization: Pathological anatomy and forensic medicine
The role of cancer microenvironment in prognosis of malignant melanomas
Žižková Veronika M.Sc.'s picture

Veronika Žižková

Doctoral training

Supervisor:
Škarda Jozef M.D., Ph.D.
Status: Ongoing
2011
Specialization:
Prognostic markers in lung cancer