Danuta Radzioch, Ph.D
Professor, Centre for the Translational Biology and Centre for Innovative Medicine at the McGill University Health Centre, Departments of Medicine and Human Genetics, McGill University, Montreal, Canada
Dr. Danuta Radzioch has been a member of Infection and Immunity Global Health Axis and Medical Genetics and Genomics Axis within the Centre for the Translational Biology and Centre for Innovative Medicine at the McGill University Health Centre. Dr Radzioch brings expertise in molecular biology, host-pathogen interactions, mouse models and translational medicine. Dr Radzioch’s laboratory has developed mouse model of cystic fibrosis lung disease and defined molecular signature of Cystic fibrosis (CF) lung disease, allergic asthma models in mice, rats and primates, mouse model of genetically controlled airway hyperresponsiveness and atopy, and mouse model of colon cancer. Team of scientists led by Dr. Radzioch focused their studies on the characterization of molecular mechanisms involved in the regulation of inflammatory response in chronic lung diseases. These studies resulted in discovery of novel pharmacological interventions which enable normalization of excessive inflammatory responses and fatty acids metabolism disturbances occurring during severe acute bacterial infections, chronic allergic responses as well as acute spinal cord injuries. The research pursued by research team led by Dr. Radzioch resulted in discovery of candidate genes regulating airway hyperresponsiveness, atopy and allergic asthma. Dr. Radzioch’ research team also explores the role of chromatin remodelling in the regulation of transcriptional regulation and the mechanisms of posttranscriptional control of genes involved in the control of inflammatory response.